Download Antiepileptic Drug Discovery: Novel Approaches by Alan Talevi, Luisa Rocha PDF

By Alan Talevi, Luisa Rocha

This thorough quantity delves into antiepileptic drug discovery with a finished selection of cutting edge methods for the improvement of antiepileptic treatments, targeting novel molecular pursuits for antiepileptic medicines, computer-aided ways for the identity of latest drug applicants, and healing suggestions to beat refractory epilepsy. The final part illustrates the aptitude merits that community pharmacology and rational drug repurposing may perhaps carry to the antiepileptic drug discovery neighborhood. Written for the Methods in Pharmacology and Toxicology sequence, chapters contain the type of distinctive description and implementation suggestion to make sure leads to the laboratory.
Authoritative and sensible, Antiepileptic Drug Discovery: Novel Approaches goals to supply medicinal chemists, pharmacologists, and different researchers with the instruments have to extra discover the research of pharmacoresistant epilepsy and the invention of recent antiepileptic drugs.

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In the CNS, degranulation of mast cells produces the release of factors such as histamine, heparin, and serotonin that can produce BBB rupture and the extravasation of blood elements to the cerebral parenchyma, situation that facilitates neuroinflammation. Therefore, it is considered that the use of drugs such as sodium cromoglycate represents a strategy to stabilize mast cells [72, 73]. The stabilizing effect of cromoglycate is carried out through the blockade of Ca2+ channels [74] and by the phosphorylation of a 78 kDa protein located around granules of mast cells that regulates the translation of signals between the membrane and the cytoskeleton [75].

Epilepsia 47(1):176–180 Che W, Parmentier J, Seidel P et al (2014) Corticosteroids inhibit sphingosine 1-phosphate-induced interleukin-6 secretion from human airway smooth muscle via mitogenactivated protein kinase phosphatase 1-mediated repression of mitogen and stress-activated protein kinase 1. Am J Respir Cell Mol Biol 50(2):358–368 García HH, Gonzales I, Lescano AG, Cysticercosis Working Group in Peru et al (2014) Enhanced steroid dosing reduces seizures during antiparasitic treatment for cysticercosis and early after.

J Neurosurg 99:907–912 Vezzani A, Moneta D, Richichi C et al (2002) Functional role of inflammatory cytokines and antiinflammatory molecules in seizures and epileptogenesis. Epilepsia 43(Suppl 5):30–35 Chiavegato A, Zurolo E, Losi G et al (2014) The inflammatory molecules IL-1β and HMGB1 can rapidly enhance focal seizure generation in a brain slice model of temporal lobe epilepsy. Front Cell Neurosci 8:155 20 María-Leonor López-Meraz et al. 40. Marchi N, Fan Q, Ghosh C et al (2009) Antagonism of peripheral inflammation reduces the severity of status epilepticus.

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