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By Robert A. Scherrer, Michael Whitehouse

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Pig (Collier, 1971), the PGF 2a may be acting in a different conformation in this species. The UV-erythema assay may be one of the best in vivo models available for the inhibition of prostaglandin synthetase. There are very few false positives from this assay. , 1967). The reverse correlation from anticarrageenan activity is not nearly as good. Because the UV-erythema assay is more specific, it appears likely that its Fig. 4 A possible conformation of PGE2 at the prostaglandin synthetase antiinflamatory receptor (absolute configuration) compared with indomethacin, a potent inhibitor.

There is no biological assay agreed on as predictive of clinical utility for this class, even though Swingle, in Volume II, lists 33 noninfectious systems for the demonstration of various activities for chloroquine. The delay in man of up to 6 months before beneficial effects are prominent makes association with laboratory assays difficult and magnifies the problems in clinical evaluation. Finally, irreversible retinopathy is a serious problem with this class of agents. , 1972). The mechanism of action of this class of agents as antiarthritics is certainly of interest because there are no other compounds like them.

Collier, H. O. J. (1967). Ann. Phys. , Suppl. pp. 50-54. Collier, H. O. J. (1971). Nature {London) 232, 17. De Gregorio, M. (1965). Int. Symp. , 1964. pp. 422-429. De Gregorio, M. (1968). Inflammation, Proc. Int. Symp. 1967. pp. 175-183. , and Willoughby, D. A. (1971). J. Pharm. Pharmacol. 23, 297. , and De Gregorio, M. (1971). -Forsch. 21, 1530. ( 1972). Nature (London), New Biol. 238, 104. Ham, E. , Cirillo, V. , Shen, T. , and Kuehl, F. , Jr. (1972). In "Prostaglandins in Cellular Biology" (P.

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