By Jean D. Sipe
A first-stop reference on proteins linked to amyloidosis. This booklet is the 1st to offer a scientific evaluate of all identified fibril-forming proteins, together with their biochemical features and pathophysiology. It considers the clinically well-known amyloid proteins which are identified to be linked to the amyloid protein folding issues, facing their universal structural and thermodynamic positive aspects that result in amyloid fibril formation and sickness. Emphasis is at the thermodynamics of protein folding, the constitution and physiologic results of universal oligomeric and subfibrillar intermediates and the effect of the extracellular matrix and mobile trafficking and metabolism at the genesis and catabolism of beta pleated sheet proteins. The chapters on particular amyloid proteins all persist with a standard constitution, permitting easy accessibility to the specified biochemical and scientific facts, making this a useful device for clinicians and researchers alike.
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Extra info for Amyloid Proteins: The Beta Sheet Conformation and Disease
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