By George Klein, Sidney Weinhouse (Eds.)
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Tumour "budding", that is all in favour of during this booklet, is mostly outlined as an remoted unmarried melanoma cellphone or a cluster composed of a really small variety of undifferentiated melanoma cells within the stroma of the actively invasive entrance. The correlation of tumour budding with medical end result in colorectal melanoma was once first mentioned within the Eighties by way of jap surgeons.
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The presence of fetal proteins in or liberated by malignant tumors has become of considerable diagnostic importance in recent years. a-feto-protein is characteristic of liver tumors, and, when present in fluid taken by amniocentesis, an indicator of spina bifida or other neural axis abnormality in the fetus. Carcinoembryonic antigen is present in the blood of most patients with an active colon carcinoma and, in smaller amount, in association with a large number of other conditions. These have been very extensively studied and no attempt to discuss their clinical significance will be made.