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By H. Arnouk

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MVA-5T4 has been assessed in conjunction with both high-dose and low-dose interleukin 2 therapy. , 2009). The results attributed a large number of adverse events to high-dose interleukin 2, but only two events (grade I fevers) to MVA-5T4, indicating that the regimen is safe and well tolerated in this population of patients. All patients developed 5T4specific antibody responses and 13 patients had an increase in 5T4-specific T cell responses. The baseline frequency of T regulatory cells was elevated in all patients, those with stable disease showed a trend toward increased effector CD8+ T cells and a decrease in T regulatory cells.

2008). 8% of patients in the observation group indicating that recurrence-free survival was not significantly improved with the vaccine. Further research is now being done to explore whether vitespen improves recurrence-free survival in patients with earlier stage disease. S. Food and Drug Administration’s fast track for approval. 2 Viral vector-based immunotherapy Treatment options for advanced metastatic disease, particularly in renal cancer, are highly toxic with few clinical benefits. Researchers are focusing on new options that produce therapeutic potential while providing a favorable toxicity profile.

Currently, vitespen is on a fast track for Food and Drug Administrationapproval in the treatment for renal cell carcinoma vaccine with further research being conducted in advanced phase clinical trials. One prostate cancer vaccine has already been approved by the Food and Drug Administration, and two more prostate cancer vaccines (TroVax and PROSTVAC) are in advanced stage trials with PROSTVAC currently seeking Food and Drug Administration approval. No vaccine currently is approved for the treatment of bladder cancer.

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