By Irvin M. Modlin MD PhD FRCS(Ed) FRCS(E, George Sachs MD ChB DSc
This textbook explores the historical past, biology, and therapy of acid comparable illnesses, together with gastric and duodenal ulcer sickness, gastroesophageal reflux affliction (GERD), and the position of H. pylori. The textual content deals thorough insurance of the subject material, with an in-depth old and organic concentration. equivalent concentration is given to the biology and pharmacology of acid secretion and to the categorical ailment states of ulcers and GERD. This variation is stuffed with new full-color clinical illustrations of all points of this topic.
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Extra resources for Acid Related Diseases: Biology and Treatment
Structural changes in the calcium pump accompanying the dissociation of calcium. Nature 2002;418:605-611. Toyoshima C, Sasabe H, Stokes DL. Three-dimensional cryoelectron microscopy of the calcium ion pump in the sarcoplasmic reticulum membrane [published erratum appears in Nature 1993;363(6426):286] Nature 1993;362:467-471. Vagin O, Munson K, Lambrecht N, et al. Mutational analysis of the K+-competitive inhibitor site of gastric H,K-ATPase. Biochemistry 2001;40:7480-7490. Walderhaug MO, Post RL, Saccomani G, et al.
45 Chapter 1 Towards An Understanding of the Physiology of the Stomach Gastric fistulae: a unique opportunity William Beaumont and the case of Alexis St. Martin William Beaumont was born on November 25, 1785, in Lebanon, Connecticut, and began his study of medicine at the age of 22 years. In the War of 1812, he accepted a position in the Army as an acting surgeon's mate and saw active service. In 1819, after a brief spell in practice, his former colleague, Joseph Lovell, who had now become Surgeon General, offered Beaumont a commission, and he was assigned to Fort Mackinac.
S. Army and paid as an experimental subject. Similarly, in 1801, Rouilly transferred to the care of Dupuytren and Bichat in Paris a patient, Madeline Gore, with a gastric fistula. Gore's gastric juice was analyzed by Clarion, a professor of chemistry, who performed the first quantitative assessment of gastric juice. Clarion found neither acid nor alkali and concluded that gastric juice was identical to saliva. This conclusion remained dogma in the French medical profession so that, even in 1812, when Montegre reported acid in fasting and mealstimulated gastric juice, he attributed this acid to the digestion of food and saliva.